Bioinformatics and immunoinformatics assisted multiepitope vaccine construct against Burkholderia anthina.

ABSTRACT: Burkholderia anthina is a pathogenic bacterial species belonging to the Burkholderiaceae family and it is mainly considered the etiological agent of chronic obstructive pulmonary diseases associated with cystic fibrosis, due to being intrinsic antibiotic resistant making it difficult to treat pulmonary infections. Hence increased rate of antibiotic-resistant bacterial species vaccine development is the priority to tackle this problem. In research work, we designed a multi-epitope-based vaccine construct against B. anthina using reverse vaccinology immunoinformatics and biophysical approaches. Based on the subtractive proteomic screening of core proteins we identified 3 probable antigenic proteins and good vaccine targets namely, type VI secretion system tube protein hc

SUBMITTER: Alshiekheid MA 

PROVIDER: S-EPMC10788630 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature