Long-term outcomes of lung cancer screening in males and females.

ABSTRACT:

Background

This study explored female and male overall mortality and lung cancer (LC) survival in two LC screening (LCS) populations, focusing on the predictive value of coronary artery calcification (CAC) at baseline low-dose computed tomography (LDCT).

Methods

This retrospective study analysed data of 6495 heavy smokers enrolled in the MILD and BioMILD LCS trials between 2005 and 2016. The primary objective of the study was to assess sex differences in all-cause mortality and LC survival. CAC scores were automatically calculated on LDCT images by a validated artificial intelligence (AI) software. Sex differences in 12-year cause-specific mortality rates were stratified by age, pack-years and CAC score.

Results

The study included 2368 females and 4127 males. The 12-y

SUBMITTER: Ruggirello M 

PROVIDER: S-EPMC10788694 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature