Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms.

ABSTRACT:

Objective

Compared to clinical bulimia nervosa, sub-threshold bulimic symptoms are becoming more prevalent in non-clinical or general population, which is repeatedly linked with the connectivity in orbitofrontal cortex (OFC), including functionally heterogeneous the medial and lateral OFC (mOFC; lOFC). However, the specific connectivity patterns of the mOFC and lOFC in individuals with severe or mild bulimic symptoms (SB; MB) remain poorly understood.

Methods

We first utilized resting-state functional connectivity (FC) and spectral dynamic causal modeling (spDCM) to investigate abnormal functional and effective connectivity (EC) of OFC subregions in adults with different severity of bulimic. The SB group (n = 21), MB group (n = 114), and healthy controls (HC, <

SUBMITTER: Li W 

PROVIDER: S-EPMC10788814 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature