MptpB Inhibitor Improves the Action of Antibiotics against <i>Mycobacterium tuberculosis</i> and Nontuberculous <i>Mycobacterium avium</i> Infections.

ABSTRACT: Treatment of Mycobacterium tuberculosis and Mycobacterium avium infections requires multiple drugs for long time periods. Mycobacterium protein-tyrosine-phosphatase B (MptpB) is a key M. tuberculosis virulence factor that subverts host antimicrobial activity to promote intracellular survival. Inhibition of MptpB reduces the infection burden in vivo and offers new opportunities to improve current treatments. Here, we demonstrate that M. avium produces an MptpB orthologue and that the MptpB inhibitor C13 reduces the M. avium infection burden in macrophages. Combining C13 with the antibiotics rifampicin or bedaquiline showed an additive effect, reducing intracellular infection of both M. tuberculosis and M. avium by 50%, compared to mono

SUBMITTER: Rodriguez-Fernandez P 

PROVIDER: S-EPMC10788870 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature