Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis.

ABSTRACT: A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and -benzothiazole Ir(III) dppz complexes [Ir(C^N)₂(dppz)]⁺, Ir1-Ir4, were rationally designed and synthesized, where the aryl group attached to the thienyl ring was p-CF₃C₆H₄ or p-Me₂NC₆H₄. These new Ir(III) complexes were assessed as photosensitizers to explore the structure-activity correlations for their potential use in biocompatible anticancer photodynamic therapy. When irradiated with blue light, the complexes exhibited high selective potency across several cancer cell lines predisposed to photodynamic therapy; the benzothiazole derivatives (Ir1 and Ir2) were the best perform

SUBMITTER: Kasparkova J 

PROVIDER: S-EPMC10788912 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature