Association of long-term exposure to various ambient air pollutants, lifestyle, and genetic predisposition with incident cognitive impairment and dementia.

ABSTRACT:

Background

Long-term exposure to air pollution has been found to contribute to the development of cognitive decline. Our study aimed to assess the association between various air pollutants and cognitive impairment and dementia. Additionally, explore the modification effects of lifestyle and genetic predisposition.

Methods

The exposure levels to various air pollutants, including particulate matter (PM) with diameters ≤ 2.5 (PM_2.5), ≤ 10 (PM₁₀), and between 2.5 and 10 μm (PM_2.5-10) and nitrogen oxides (NO and NO₂) were identified. An air pollution score (APS) was calculated to evaluate the combined exposure to these five air pollutants. A genetic risk estimate and healthy lifestyle score (HLS) were also generated. The Cox regression

SUBMITTER: Ge R 

PROVIDER: S-EPMC10788974 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature