Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study.

ABSTRACT:

Background

Observational studies and randomized controlled trials have found evidence that higher maternal circulating cortisol levels in pregnancy are associated with lower offspring birth weight. However, it is possible that the observational associations are due to residual confounding.

Methods

We performed two-sample Mendelian Randomisation (MR) using a single genetic variant (rs9989237) associated with morning plasma cortisol (GWAS; sample 1; N = 25,314). The association between this maternal genetic variant and offspring birth weight, adjusted for fetal genotype, was obtained from the published EGG Consortium and UK Biobank meta-analysis (GWAS; sample 2; N = up to 406,063) and a Wald ratio was used to estimate the causal effect. We also performed an alternative analysi

SUBMITTER: Thompson WD 

PROVIDER: S-EPMC10789047 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature