Resveratrol-βcd inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy.

ABSTRACT:

Background

The ovarian environment of premature ovarian insufficiency (POI) patients exhibits immune dysregulation, which leads to excessive secretion of numerous proinflammatory cytokines that affect ovarian function. An abnormal level of macrophage polarization directly or indirectly inhibits the differentiation of ovarian granulosa cells and steroid hormone production, ultimately leading to POI. Resveratrol, as a health supplement, has been widely recognized for its safety. There is a substantial amount of evidence indicating that resveratrol and its analogs possess significant immune-regulatory functions. It has also been reported that resveratrol can effectively inhibit the progression of POI. However, the underlying immunological and molecular mechanisms through which resvera

SUBMITTER: Hu B 

PROVIDER: S-EPMC10789063 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature