Low-Dose Trypsin Accelerates Wound Healing via Protease-Activated Receptor 2.

ABSTRACT: The management of wounds remains a significant healthcare challenge, highlighting the need for effective wound healing strategies. To address this, it is crucial to explore the molecular mechanisms underlying tissue repair as well as explore potential therapeutic approaches. Trypsin, as a serine protease, has been clinically utilized for wound healing for decades; however, it still lacks systemic investigation on its role and related mechanism. This study aimed to investigate the effects of low-dose trypsin on wound healing both in vitro and in vivo. While trypsin is an endogenous stimulus for protease-activated receptor 2 (PAR2), we discovered that both low-dose trypsin and synthesized PAR2 agonists significantly enhanced the migration, adhesion, and proliferation of fibrobl

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC10789143 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature