Increased white matter fibre dispersion and lower IQ scores in adults born preterm.

ABSTRACT: Preterm birth has been associated with altered microstructural properties of the white matter and lower cognitive ability in childhood and adulthood. Due to methodological limitations of the diffusion tensor model, it is not clear whether alterations in myelination or variation in fibre orientation are driving these differences. Novel models applied to multi-shell diffusion imaging have been used to disentangle these effects, but to date this has not been used to study the preterm brain in adulthood. This study investigated whether novel advanced diffusion MRI metrics such as microscopic anisotropy and orientation dispersion are altered in adults born preterm, and whether this was associated with cognitive performance. Seventy-two preterm born participants (<37 weeks gestational age) were

SUBMITTER: Lapidaire W 

PROVIDER: S-EPMC10789207 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature