The volume and the distribution of premorbid white matter hyperintensities: Impact on post-stroke aphasia.

ABSTRACT: White matter hyperintensities (WMH) are a radiological manifestation of progressive white matter integrity loss. The total volume and distribution of WMH within the corpus callosum have been associated with pathological cognitive ageing processes but have not been considered in relation to post-stroke aphasia outcomes. We investigated the contribution of both the total volume of WMH, and the extent of WMH lesion load in the corpus callosum to the recovery of language after first-ever stroke. Behavioural and neuroimaging data from individuals (N = 37) with a left-hemisphere stroke were included at the early subacute stage of recovery. Spoken language comprehension and production abilities were assessed using word and sentence-level tasks. Neuroimaging data was used to derive stroke lesion v

SUBMITTER: Vadinova V 

PROVIDER: S-EPMC10789210 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature