Baseline GABA+ levels in areas associated with sensorimotor control predict initial and long-term motor learning progress.

ABSTRACT: Synaptic plasticity relies on the balance between excitation and inhibition in the brain. As the primary inhibitory and excitatory neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate (Glu), play critical roles in synaptic plasticity and learning. However, the role of these neurometabolites in motor learning is still unclear. Furthermore, it remains to be investigated which neurometabolite levels from the regions composing the sensorimotor network predict future learning outcome. Here, we studied the role of baseline neurometabolite levels in four task-related brain areas during different stages of motor skill learning under two different feedback (FB) conditions. Fifty-one healthy participants were trained on a bimanual motor task over 5 days while receiving either concurrent a

SUBMITTER: Li H 

PROVIDER: S-EPMC10789216 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature