The impact of study factors in the association of periodontal disease and cognitive disorders: systematic review and meta-analysis.

ABSTRACT:

Aim

The aim was to assess study factors that impact the association of cognitive disorders in people with periodontal disease (PD).

Method

Medline, EMBASE and Cochrane databases were searched until February 2022 using keywords and MeSH: (periodon* OR tooth loss OR missing teeth) AND (dementia OR Alzheimer's Disease OR cognitive*). Observational studies reporting prevalence or risk of cognitive decline, dementia or Alzheimer's disease (AD) in people with PD compared with healthy controls were included. Meta-analysis quantified the prevalence and risk (relative risk[RR]) of cognitive decline, dementia/AD, respectively. Meta-regression/subgroup analysis explored the impact of study factors including PD severity and classification type, and gender.

Results

Overall, 39 stu

SUBMITTER: Larvin H 

PROVIDER: S-EPMC10789237 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature