Dysbiosis of the Beneficial Gut Bacteria in Patients with Parkinson's Disease from India.

ABSTRACT:

Objectives

Recent advancement in understanding neurological disorders has revealed the involvement of dysbiosis of the gut microbiota in the pathophysiology of Parkinson's disease (PD). We sequenced microbial DNA using fecal samples collected from PD cases and healthy controls (HCs) to evaluate the role of gut microbiota.

Methods

Full-length bacterial 16S rRNA gene sequencing of fecal samples was performed using amplified polymerase chain reaction (PCR) products on the GridION Nanopore sequencer. Sequenced data were analyzed using web-based tools BugSeq and MicrobiomeAnalyst.

Results

We found that certain bacterial families like Clostridia UCG 014, Cristensenellaceae, and Oscillospiraceae are higher in abundance, and Lachinospiracea, Coriobacteriaceae and genera assoc

SUBMITTER: Pavan S 

PROVIDER: S-EPMC10789430 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature