Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.

ABSTRACT: We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10789563 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature