Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3.

ABSTRACT:

Background

Tau is a microtubule-binding protein encoded by the MAPT gene. Tau is essential for several physiological functions and associated with pathological processes, including Alzheimer's disease (AD). Six tau isoforms are typically described in the central nervous system, but current research paints a more diverse landscape and a more nuanced balance between isoforms. Recent work has described tau isoforms generated by intron 11 and intron 12 retention. This work adds to that evidence, proving the existence of MAPT transcripts retaining intron 3. Our aim is to demonstrate the existence of mature MAPT RNA species that retain intron 3 in human brain samples and to study its correlation with Alzheimer's disease across different regions.

Methods

Initial evidence of intron-

SUBMITTER: Ruiz-Gabarre D 

PROVIDER: S-EPMC10789595 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature