Major lipids and lipoprotein levels and risk of blood pressure elevation: a Mendelian Randomisation study.

ABSTRACT:

Background

Quantitative nuclear magnetic resonance (NMR) metabolomics techniques provide detailed measurements of lipoprotein particle concentration. Metabolic dysfunction often represents a cluster of conditions, including dyslipidaemia, hypertension, and diabetes, that increase the risk of cardiovascular diseases (CVDs). However, the causal relationship between lipid profiles and blood pressure (BP) remains unclear. We performed a Mendelian Randomisation (MR) study to disentangle and prioritize the potential causal effects of major lipids, lipoprotein particles, and circulating metabolites on BP and pulse pressure (PP).

Methods

We employed single-nucleotide polymorphisms (SNPs) associated with major lipids, lipoprotein particles, and other metabolites from the UK Biobank a

SUBMITTER: Liu W 

PROVIDER: S-EPMC10789600 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature