A chromogenic diarylethene-based probe for the detection of Cu²⁺ in aqueous medium in Drosophila for early diagnosis of Alzheimer.

ABSTRACT: A diarylethene-based probe (Z)-N'-((2-amino-5-chlorophenyl)(phenyl)methylene)-2-hydroxy benzohydrazide (KBH) has been proficiently developed and its structure has been confirmed by single crystal X-ray diffraction technique. It displays a selective and sensitive colorimetric sensing of Cu²⁺ ions in aqueous medium with a naked eye colour change from colourless to yellow. It exhibits a significantly low limit of detection as 1.5 nM. A plausible binding mechanism has been proposed using Job's plot, FT-IR, ¹H NMR titration, HRMS and DFT studies. The chemosensor is effectively reversible and reusable with EDTA. Test strip kit and real water sample analysis have been shown to establish its practical applicability. Further, the potential of KBH for the e

SUBMITTER: Kumar G 

PROVIDER: S-EPMC10789622 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature