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ADP-ribosylation from molecular mechanisms to therapeutic implications.

ABSTRACT: ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has reshaped our understanding of the molecular mechanisms that govern the establishment, removal, and recognition of this modification, as well as its impact on cellular and organismal function. These advances have also revealed the intricate involvement of ADP-ribosylation in human physiology and pathology and the enormous potential that their manipulation holds for therapy. In this review, we present the state-of-the-art findings covering the work in structural biology, biochemistry, cell biology, and clinical aspects of ADP-ribosylation.

SUBMITTER: Suskiewicz MJ

PROVIDER: S-EPMC10789625 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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ADP-ribosylation from molecular mechanisms to therapeutic implications.

Suskiewicz Marcin J MJ Prokhorova Evgeniia E Rack Johannes G M JGM Ahel Ivan I

Cell 20231001 21

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has reshaped our understanding of the molecular mechanisms that govern the establishment, removal, and recognition of this modification, as well as its impact on cellular and organismal function. These advances have also revealed the intricate involvement of ADP-ri ...[more]

PMID: 37832523

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ADP-ribosylation: from molecular mechanisms to human disease.

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