Quantum dots-based "chemical tongue" for the discrimination of short-length Aβ peptides.

ABSTRACT: A "chemical tongue" is proposed based on thiomalic acid-capped quantum dots (QDs) with signal enrichment provided by excitation-emission matrix (EEM) fluorescence spectroscopy for the determination of close structural analogs-short-length amyloid β (Aβ) peptides related to Alzheimer's disease. Excellent discrimination is obtained by principal component analysis (PCA) for seven derivatives: Aβ_1-16, Aβ_4-16, Aβ_4-9, Aβ_5-16, Aβ_5-12, Aβ_5-9, Aβ_12-16. Detection of Aβ_4-16, Aβ_4-16, and Aβ_5-9 in binary and ternary mixtures performed by QDs-based chemical tongue using partial least squares-discriminant analysis (PLS-DA) provided perfect 100% accuracy for the two studied peptides (Aβ_4-16</

SUBMITTER: Glowacz K 

PROVIDER: S-EPMC10789672 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature