Reproductive outcomes in couples with recurrent pregnancy loss after embryonic chromosomal microarray analysis.

ABSTRACT:

Background

Chromosomal microarray analysis (CMA) has been widely applied to explore the genetic etiology in recurrent pregnancy loss (RPL). However, the reproductive prognosis in RPL couples with different types of chromosomally abnormal miscarriage remains unclear.

Objectives

The main purpose of this study was to evaluate the reproductive prognosis among RPL couples after genetic testing in products of conception (POCs) by CMA.

Study design

In this retrospective study, 1101 RPL couples referred for genetic testing in POCs by CMA. A total of 830 couples who met the inclusion criteria were followed up for at least 24 months after the index miscarriage. The rates of live birth and adverse pregnancy events in subsequent pregnancy and cumulative pregnancies were examined.

SUBMITTER: Li Y 

PROVIDER: S-EPMC10789713 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature