Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.

ABSTRACT: Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility is important for successful attainment of goals, as well as for social interactions, and is frequently impaired in neuropsychiatric disorders, including obsessive-compulsive disorder. However, a unifying mechanistic framework accounting for the role of serotonin in behavioral flexibility has remained elusive. Here, we demonstrate common effects of manipulating serotonin function across two species (rats and humans) on latent processes supporting choice behavior during probabilistic reversal learning, using computational modelling. The findings support a role of serotonin in behavioral flexibility and plasticity, indicated, respectively, by increases or decreases in choice repe

SUBMITTER: Luo Q 

PROVIDER: S-EPMC10789782 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature