Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis.

ABSTRACT: Despite regulatory elements such as long non - coding RNAs representing most of the transcriptome, the functional understanding of long non - coding RNAs in relation to major health conditions including bovine mastitis is limited. This study examined the milk somatic cell transcriptome from udder quarters of 6 Holstein dairy cows to identify differentially expressed long non - coding RNAs using RNA - Sequencing. Ninety - four differentially expressed long non - coding RNAs are identified, 5 of which are previously annotated for gene name and length, 11 are annotated for gene name and 78 are novel, having no gene name or length previously annotated. Significant inflammatory response and regulation of immune response pathways (false discovery rate < 0.05) are associated with the differential

SUBMITTER: Asselstine V 

PROVIDER: S-EPMC10789785 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature