Hyperglycaemia, diabetes and risk of fragility fractures: observational and Mendelian randomisation studies.

ABSTRACT:

Aims/hypothesis

Fragility fractures may be a complication of diabetes, partly caused by chronic hyperglycaemia. We hypothesised that: (1) individuals with hyperglycaemia and diabetes have increased risk of fragility fracture; (2) hyperglycaemia is causally associated with increased risk of fragility fracture; and (3) diabetes and fragility fracture jointly associate with the highest risk of all-cause mortality.

Methods

In total, 117,054 individuals from the Copenhagen City Heart Study and the Copenhagen General Population Study (the Copenhagen studies) and 390,374 individuals from UK Biobank were included for observational and one-sample Mendelian randomisation (MR) analyses. Fragility fractures were defined as fractures at the hip, spine and arm (humerus/wrist), collected f

SUBMITTER: Emanuelsson F 

PROVIDER: S-EPMC10789835 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature