Effects of maternal type 1 diabetes and confounding factors on neonatal microbiomes.

ABSTRACT:

Aims/hypothesis

Body niche-specific microbiota in maternal-neonatal dyads from gravidae with type 1 diabetes have not been quantitatively and functionally examined. Similarly, the impact of pregnancy-specific factors, such as the presence of comorbidities known to occur more frequently among gravidae with type 1 diabetes, including Caesarean delivery, as well as antibiotic prophylaxis, level of glycaemic control during each trimester of pregnancy and insulin administration, has not been adequately considered. The aims of this study were to characterise the maternal and neonatal microbiomes, assess aspects of microbiota transfer from the maternal microbiomes to the neonatal microbiome and explore the impact of type 1 diabetes and confounding factors on the microbiomes.

Methods

SUBMITTER: Gajecka M 

PROVIDER: S-EPMC10789840 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature