The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis.

ABSTRACT:

Background

Osteoarthritis (OA) is a chronic degenerative joint disease that primarily affects middle-aged and elderly individuals. The decline in chondrocyte function plays a crucial role in the development of OA. Inflammasome-mediated chondrocyte pyroptosis is implicated in matrix degradation and cartilage degeneration in OA patients. Guanylate binding protein 5 (GBP5), a member of the GTPase family induced by Interferon-γ (IFN-γ), significantly influences cellular inflammatory responses, including intracellular inflammasome activation and cytokine release. However, the role of GBP5 in chondrocyte pyroptosis and OA progression remains unclear.

Methods

In this study, we used tumor necrosis factor-α (TNF-α) to induce inflammation and created an OA mouse model with surgically-

SUBMITTER: Tang H 

PROVIDER: S-EPMC10789940 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature