Cerebrospinal fluid and plasma ascorbate concentrations following subarachnoid haemorrhage.

ABSTRACT:

Background

Ascorbate, the biologically active form of vitamin C, is the primary neural anti-oxidant. Ascorbate concentrations have never been quantified following aneurysmal subarachnoid haemorrhage (aSAH).

Objective

To quantify plasma and cerebrospinal fluid (CSF) ascorbate concentrations in patients following SAH.

Design setting participants main outcome measures

Cohort study in which plasma and CSF ascorbate concentrations were measured longitudinally in 12 aSAH patients admitted to a quaternary referral intensive care unit and compared to one-off samples obtained from 20 pregnant women prior to delivery in a co-located obstetric hospital. Data are median [interquartile range] or median (95 % confidence intervals).

Results

Forty-eight plasma samples were obt

SUBMITTER: Turner N 

PROVIDER: S-EPMC10790009 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature