The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management.

ABSTRACT: Severe traumatic brain injury (TBI) is a major cause of morbidity and mortality globally. The Brain Trauma Foundation guidelines advocate for the maintenance of a cerebral perfusion pressure (CPP) between 60 and 70 mmHg following severe TBI. However, such a uniform goal does not account for changes in cerebral autoregulation (CA). CA refers to the complex homeostatic mechanisms by which cerebral blood flow is maintained, despite variations in mean arterial pressure and intracranial pressure. Disruption to CA has become increasingly recognised as a key mediator of secondary brain injury following severe TBI. The pressure reactivity index is calculated as the degree of statistical correlation between the slow wave components of mean arterial pressure and intracranial pressure signals and is

SUBMITTER: Tsigaras ZA 

PROVIDER: S-EPMC10790019 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature