Construction of brain metastasis prediction model in limited stage small cell lung cancer patients without prophylactic cranial irradiation.

ABSTRACT:

Introduction

Small cell lung cancer (SCLC) is a highly aggressive lung cancer variant known for its elevated risk of brain metastases (BM). While earlier meta-analyses supported the use of prophylactic cranial irradiation (PCI) to reduce BM incidence and enhance overall survival, modern MRI capabilities raise questions about PCI's universal benefit for limited-stage SCLC (LS-SCLC) patients. As a response, we have created a predictive model for BM, aiming to identify low-risk individuals who may not require PCI.

Methods

A total of 194 LS-SCLC patients without PCI treated between 2009 and 2021 were included. We conducted both univariate and multivariate analyses to pinpoint the factors associated with the development of BM. A nomogram for predicting the 2- and 3-year probabili

SUBMITTER: Guo J 

PROVIDER: S-EPMC10790059 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature