Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses.

ABSTRACT:

Background

Although extensive discussions on the influence of maternal educational attainment on offspring birthweight, the conclusion remains controversial, and it is challenging to comprehensively assess the causal association between them.

Methods

To estimate effect of maternal educational attainment on the birthweight of first child, we first conducted an individual-level analysis with UK Biobank participants of white ancestry (n = 208,162). We then implemented Mendelian randomization (MR) methods including inverse variance weighted (IVW) MR and multivariable MR to assess the causal relation between maternal education and maternal-specific birthweight. Finally, using the UK Biobank parent-offspring trio data (n = 618), we performed a polygenic score based M

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10790093 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature