Eleven years of alloimmunization in 6496 patients with sickle cell disease in France who received transfusion.

ABSTRACT:

Abstract

Red blood cell (RBC) transfusion is a major therapy for sickle cell disease (SCD). Patients are at risk of forming antibodies to RBC antigens, which can result in the impossibility to find compatible units and can cause hemolytic transfusion reactions. This retrospective study investigates the evolution of RBC consumption and the frequencies, specificities, and chronology of the appearance of antibodies in a population of patients consistently receiving RH (C, D, E, c, e) and K-matched RBC units (RBCus) from a predominantly European donor population. Over the 11-year period in the Paris area, 6496 patients received transfusion at least once for a total of 239 944 units. Antibodies were made by 1742 patients. The first antibodies of a patient were predictive of subsequent i

SUBMITTER: Floch A 

PROVIDER: S-EPMC10790094 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature