Association of Metabolic Syndrome With Risk of Lung Cancer: A Population-Based Prospective Cohort Study.

ABSTRACT:

Background

Both the incidence of lung cancer and the prevalence of metabolic syndrome (MetS) have been increasing worldwide. The relationship between MetS and lung cancer remains controversial.

Research question

What is the risk of lung cancer associated with MetS and its components?

Study design and methods

Multivariable Cox regression models were used to estimate the hazard ratio (HR) of MetS-related variables on lung cancer risk, both overall and by histologic subtype, in the UK Biobank. Stratified analyses were conducted by sex, tobacco use status, and use of medication. HR curves were used to test the nonlinear associations between the metabolic markers and the risk of lung cancer.

Results

Of the 331,877 participants included in this study, a total of 77,1

SUBMITTER: Li M 

PROVIDER: S-EPMC10790176 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature