A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.

ABSTRACT: In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quickly. The SARS-CoV-2 pandemic has shown that integrating critical data resources to drive drug-repositioning studies, involving host-host, host-pathogen, and drug-target interactions, remains a time-consuming effort that translates to a delay in the development and delivery of a life-saving therapy. Here, we describe a workflow we designed for a semiautomated integration of rapidly emerging data sets that can be generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that

SUBMITTER: Zahoranszky-Kohalmi G 

PROVIDER: S-EPMC10790216 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature