Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets.

ABSTRACT: CD69+CD103+ tissue-resident memory T (T_RM) cells are important drivers of inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high-dimensional profiling to T cells from the joints of patients with psoriatic arthritis (PsA) or rheumatoid arthritis (RA). We identify three groups of synovial CD8+CD69+CD103+ T_RM cells: cytotoxic and regulatory T (Treg)-like T_RM cells are present in both PsA and RA, while CD161+CCR6+ type 17-like T_RM cells with a pro-inflammatory cytokine profile (IL-17A+TNFα+IFNγ+) are specifically enriched in PsA. In contrast, only one population of CD4+CD69+CD103+ T_RM cells is detected and at similarly low frequencies in both diseases. Type 17-like CD8+ T_RM cells have a distin

SUBMITTER: Povoleri GAM 

PROVIDER: S-EPMC10790246 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature