Postoperative pain after different doses of remifentanil infusion during anaesthesia: a meta-analysis.

ABSTRACT:

Background

This meta-analysis aimed to explore the correlation between the different doses of remifentanil-based anaesthesia and postoperative pain in randomised trials.

Methods

The electronic databases including PubMed, Cochrane, clinical trial registries, and Google Scholar were searched up to November 2022 for randomised controlled trials (RCTs) that assessed the dose dependent efficacy of remifentanil for postoperative pain intensity and hyperalgesia.

Results

31 studies involving 2019 patients were included for analysis. Compared with the high remifentanil dose administration, patients in low doses showed less postoperative pain intensity at 1-2 h (weighted mean differences (WMD): 0.60, 95% CI, 0.05 to 1.15), 3-8 h (WMD: 0.38, 95% CI, 0.00 to 0.75), 24 h (WMD: 0.2

SUBMITTER: Huang X 

PROVIDER: S-EPMC10790271 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature