Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells.

ABSTRACT:

Background

Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mechanism of atherosclerosis progression through tar-induced VSMC necroptosis, a recently described form of necrosis.

Methods

The effect of tar on atherosclerosis progression and VSMC necroptosis was examined in ApoE^-/- mice and cultured VSMCs. The role of necroptosis in tar-induced plaque development was evaluated in RIPK3-deletion mice (ApoE^-/-RIPK3^-/-). The key proteins of necroptosis in carotid plaques of smokers and non-smokers were also examined. Quantit

SUBMITTER: Bai X 

PROVIDER: S-EPMC10790416 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature