Exploring small non-coding RNAs as blood-based biomarkers to predict Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) diagnosis relies on clinical symptoms complemented with biological biomarkers, the Amyloid Tau Neurodegeneration (ATN) framework. Small non-coding RNA (sncRNA) in the blood have emerged as potential predictors of AD. We identified sncRNA signatures specific to ATN and AD, and evaluated both their contribution to improving AD conversion prediction beyond ATN alone.

Methods

This nested case-control study was conducted within the ACE cohort and included MCI patients matched by sex. Patients free of type 2 diabetes underwent cerebrospinal fluid (CSF) and plasma collection and were followed-up for a median of 2.45-years. Plasma sncRNAs were profiled using small RNA-sequencing. Conditional logistic and Cox regression analyses with elastic net pe

SUBMITTER: Gutierrez-Tordera L 

PROVIDER: S-EPMC10790437 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature