The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the connection between immunological inflammation and AS, however, has shown inconclusive results.

Methods

To evaluate the causal association between immunological characteristics and AS, a bidirectional, two-sample Mendelian randomization (MR) approach was performed in this study. We investigated the causal connection between 731 immunological feature characteristic cells and AS risk using large, publically available genome-wide association studies.

Results

After FDR correction, two immu

SUBMITTER: Fei Y 

PROVIDER: S-EPMC10790477 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature