Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide. We aimed to summarize what is currently known with regard to causal modifiable risk factors associated with CAD in populations of diverse ancestries through conducting a systematic review and meta-analysis of Mendelian randomization (MR) studies on CAD.

Methods

The databases Embase, Medline, Cochrane Library and Web of Science were searched on the 19th and 20th of December 2022 for MR studies with CAD as a primary outcome; keywords of the search strategy included "coronary artery disease" and "mendelian randomization". Studies were included if they were published in the English language, included only human participants, employed Mendelian randomization as the primary methodolo

SUBMITTER: Silva S 

PROVIDER: S-EPMC10790478 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature