Genome-scale metabolic network model and phenome of solvent-tolerant Pseudomonas putida S12.

ABSTRACT:

Background

Pseudomonas putida S12 is a gram-negative bacterium renowned for its high tolerance to organic solvents and metabolic versatility, making it attractive for various applications, including bioremediation and the production of aromatic compounds, bioplastics, biofuels, and value-added compounds. However, a metabolic model of S12 has yet to be developed.

Results

In this study, we present a comprehensive and highly curated genome-scale metabolic network model of S12 (iSH1474), containing 1,474 genes, 1,436 unique metabolites, and 2,938 metabolic reactions. The model was constructed by leveraging existing metabolic models and conducting comparative analyses of genomes and phenomes. Approximately 2,000 different phenotypes were measured for S12 and its closely related K

SUBMITTER: Han S 

PROVIDER: S-EPMC10790481 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature