The causal relationship between COVID-19 and estimated glomerular filtration rate: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Previous Mendelian studies identified a causal relationship between renal function, as assessed by estimated glomerular filtration rate (eGFR), and severe infection with coronavirus disease 2019 (COVID-19). However, much is still unknown because of the limited number of associated single nucleotide polymorphisms (SNPs) of COVID-19 and the lack of cystatin C testing. Therefore, in the present study, we aimed to determine the genetic mechanisms responsible for the association between eGFR and COVID-19 in a European population.

Methods

We performed bidirectional Mendelian randomization (MR) analysis on large-scale genome-wide association study (GWAS) data; log-eGFR was calculated from the serum levels of creatinine or cystatin C by applying the Chronic Kidney Disease

SUBMITTER: Li Q 

PROVIDER: S-EPMC10790484 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature