Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress.

ABSTRACT:

Background

Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media and organisms. It has certain reproductive toxicity and can cause a variety of female reproductive system diseases. Although BPA-stimulated apoptosis of granulosa cells has been widely elaborated, the effect of BPA on mouse pre-antral follicle granulosa cells (mpGCs) has not been well elucidated.

Results

In this study, the results of live-dead cell staining showed that high concentrations of BPA severely impaired mpGCs growth viability and affected the cell cycle transition of mpGCs. We confirmed that BPA promotes the production of reactive oxygen species (ROS) and facilitates oxidative stress in mpGCs. In addition

SUBMITTER: Wang C 

PROVIDER: S-EPMC10790560 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature