Ontology highlight
ABSTRACT:
SUBMITTER: Barrington CL
PROVIDER: S-EPMC10790568 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Barrington Chloe L CL Galindo Gabriel G Koch Amanda L AL Horton Emma R ER Morrison Evan J EJ Tisa Samantha S Stasevich Timothy J TJ Rissland Olivia S OS
Cell reports 20231212 12
Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA) degradation. Nevertheless, transcript levels are often insufficient to explain protein levels, suggesting additional mechanisms by which codon usage regulates gene expression. Using reporters in human and Drosophila cells, we find that transcript levels acco ...[more]