Dysregulation of Long Intergenic Non-Coding RNA Expression in the Schizophrenia Brain.

ABSTRACT:

Background

Transcriptomic studies of the brains of schizophrenia (SZ) patients have produced abundant but largely inconsistent findings about the disorders pathophysiology. These inconsistencies might stem not only from the heterogeneous nature of the disorder, but also from the unbalanced focus on particular cortical regions and protein-coding genes. Compared to protein-coding transcripts, long intergenic non-coding RNA (lincRNA) display substantially greater brain region and disease response specificity, positioning them as prospective indicators of SZ-associated alterations. Further, a growing understanding of the systemic character of the disorder calls for a more systematic screening involving multiple diverse brain regions.

Aim

We aimed to identify and interpret altera

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC10790728 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature