Genetic Polymorphisms of GSTM1 and GPX1 Genes and Smoking Susceptibility in the Saudi Population.

ABSTRACT:

Background/objective/methods

Glutathione-S-transferase Mu1 (GSTM1) and glutathione peroxidase 1 (GPX1) are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between GSTM1 and GPX1 levels between a group of smokers with the GSTM1 and GPX1 genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers.

Results

The control and smokers' group (n = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m²) were genotyped using quantitative polymerase chain reaction (qPCR). In comparison with the control group, the smokers' group displayed a different genotype disruption of GSTM1 and

SUBMITTER: Al-Zahrani MH 

PROVIDER: S-EPMC10790742 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature