Identification of two anti-Candida antibodies associated with the survival of patients with candidemia.

ABSTRACT:

Importance

Candidemia (bloodstream invasion by Candida species) is a major fungal disease in humans. Despite the recent progress in diagnosis and treatment, therapeutic options are limited and under threat of antimicrobial resistance. The disease mortality remains high (around 40%). In contrast with deep-seated invasive candidiasis, particularly that occurring in patients with hematologic malignancies and organ transplants, patients with candidemia are often not immunocompromised and therefore able to mount memory anticandidal immune responses, perhaps primed by Candida commensalism. We investigated antibody immunity in candidemia patients and report here on the ability of these patients to produce antibodies that react with Candida antigens. In particular, the

SUBMITTER: Bromuro C 

PROVIDER: S-EPMC10790786 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature