Teratoma pathology and genomics in anti-NMDA receptor encephalitis.

ABSTRACT:

Introduction

Ovarian teratoma is a common occurrence in patients with anti-NMDA receptor encephalitis (NMDARe), and its removal is crucial for a favorable prognosis. However, the initial pathogenesis of autoimmunity in the encephalitic teratoma remains unclear. In this study, we aimed to investigate the genomic landscape and microscopic findings by comparing NMDARe-associated teratomas and non-encephalitic control teratomas.

Materials and methods

A prospective consecutive cohort of 84 patients with NMDARe was recruited from January 2014 to April 2020, and among them, patients who received teratoma removal surgery at Seoul National University Hospital were enrolled. We conducted a comparison of whole-exome sequencing data and pathologic findings between NMDARe-associated tera

SUBMITTER: Jang Y 

PROVIDER: S-EPMC10791014 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature