Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study.

ABSTRACT:

Background and objectives

Ethanol has been reported to improve tremor severity in approximately two thirds of patients with essential tremor (ET), but the accuracy of that proportion is not certain and the mechanism of action is unknown. The goal of this study was to investigate alcohol response on tremor by applying an a priori objective response definition and subsequently to describe the responder rate to a standardized ethanol dose in a cohort of 85 ET patients. A secondary analysis evaluated other tremor and nontremor features, including demographics, tremor intensity, breath alcohol concentration, nontremor effects of alcohol, self-reported responder status to ethanol, and prior ethanol exposure.

Methods

This was a prospective, open-label, single-dose challenge of oral

SUBMITTER: McGurrin P 

PROVIDER: S-EPMC10791018 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature