Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis.

ABSTRACT:

Objective

Retrograde trans-synaptic neuroaxonal degeneration is considered a key pathological factor of subclinical retinal neuroaxonal damage in multiple sclerosis (MS). We aim to evaluate the longitudinal association of optic radiation (OR) lesion activity with retinal neuroaxonal damage and its role in correlations between retinal and brain atrophy in people with clinically isolated syndrome and early MS (pweMS).

Methods

Eighty-five pweMS were retrospectively screened from a prospective cohort (Berlin CIS cohort). Participants underwent 3T magnetic resonance imaging (MRI) for OR lesion volume and brain atrophy measurements and optical coherence tomography (OCT) for retinal layer thickness measurements. All pweMS were followed with serial OCT and MRI over a median follow-u

SUBMITTER: Lin TY 

PROVIDER: S-EPMC10791029 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature