The role of the amygdala in ictal central apnea: insights from brain MRI morphometry.

ABSTRACT:

Objective

Ictal central apnea (ICA) is a frequent correlate of focal seizures, particularly in temporal lobe epilepsy (TLE), and regarded as a potential electroclinical biomarker of sudden unexpected death in epilepsy (SUDEP). Aims of this study are to investigate morphometric changes of subcortical structures in ICA patients and to find neuroimaging biomarkers of ICA in patients with focal epilepsy.

Methods

We prospectively recruited focal epilepsy patients with recorded seizures during a video-EEG long-term monitoring with cardiorespiratory polygraphic recordings from April 2020 to September 2022. Participants were accordingly subdivided into two groups: patients with focal seizures with ICA (ICA) and without (noICA). A pool of 30 controls matched by age and sex was collec

SUBMITTER: Micalizzi E 

PROVIDER: S-EPMC10791031 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature